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PATIENT SUPPORT SERVICES
The JazzCares Program is sponsored by Jazz Pharmaceuticals to help improve access to Jazz products for appropriate patients. Dedicated JazzCares specialists are available to assist patients and practices with coverage and reimbursement support for DEFITELIO.
Help understanding insurance coverage
Provide resources to help patients understand their insurance coverage and find information on sources of financial support
Free-drug program for eligible patients
Designed to provide DEFITELIO at no cost to patients who are uninsured or deemed uninsured due to lack of coverage for DEFITELIO
Subject to financial and residency eligibility criteria
Call the patient support hotline 1-888-837-4397, Monday through Friday between 8 AM and 8 PM ET to speak with a representative.
Insurance coverage and plans may vary. The JazzCares program provides general information only and is not a guarantee of any coverage or reimbursement outcome. All treatment decisions rest solely with the treating physician or qualified healthcare professional.
You can also request to be contacted by an Access and Reimbursement Manager (ARM) to assist you with additional reimbursement-related questions.
Defitelio® (defibrotide sodium) is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).
IMPORTANT SAFETY INFORMATION
Defitelio is contraindicated in the following conditions:
- Concomitant administration with systemic anticoagulant or fibrinolytic therapy
- Known hypersensitivity to Defitelio or to any of its excipients
Warnings and Precautions
Defitelio may increase the risk of bleeding in patients with VOD after HSCT. Do not initiate Defitelio in patients with active bleeding. Monitor patients on Defitelio for signs of bleeding. If bleeding occurs, withhold or discontinue Defitelio.
Concomitant systemic anticoagulant or fibrinolytic therapy may increase the risk of bleeding and should be discontinued prior to Defitelio treatment. Consider delaying Defitelio administration until the effects of the anticoagulant have abated.
Hypersensitivity reactions including rash, urticaria, and angioedema have occurred in less than 2% of patients treated with Defitelio. One case of an anaphylactic reaction was reported in a patient who had previously received Defitelio. Monitor patients for hypersensitivity reactions, especially if there is a history of previous exposure. If a severe hypersensitivity reaction occurs, discontinue Defitelio, treat according to the standard of care, and monitor until symptoms resolve.
Most Common Adverse Reactions
The most common adverse reactions (incidence ≥10% and independent of causality) with Defitelio treatment were hypotension, diarrhea, vomiting, nausea, and epistaxis.Please see full Prescribing Information.